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Syllabus

Biostatistical Methods for Clinical Research II BIOSTAT208

Date/Time Activity Topic/Content Faculty Locations
Tues 1/5/2010
10:30 AM-12:00 PM		Lecture

Introduction and Exploratory Analysis

Class organization; importance of data exploration; regression overview

Required Reading:

  1. Chapters 1-2, VGSM

Note/Slide Files: Biostat_208_duedates_2010.pdf (28 KB) Biostat_208_Syllabus-10.pdf (94 KB) lecture1-handout-4up.pdf (2208 KB) lecture1-handout.pdf (2243 KB)

Assignment:
Homework #1: Due Date: 01/26/10

Assignment Files: hw1-VGSM-problems.pdf (55 KB) hw1.pdf (55 KB)

Assignment Answer Files: hw1-solutions.pdf (374 KB)

Dataset Files: problem2-4.dta (1 KB) problem2-5.dta (1 KB) wcgs.dta (64 KB)

S ShiboskiCB 6702
Thurs 1/7/2010
10:30 AM-12:30 PM		Lab

Introduction

Assignment Files: lab1.pdf (137 KB)

Assignment Answer Files: lab1.comments.pdf (86 KB)

Dataset Files: lab1.dta (2 KB)

S ShiboskiCB 6704
Tues 1/12/2010
10:30 AM-12:00 PM		Lecture

Multiple Linear Regression

Regression with a single binary or continuous predictor; Multiple regression

Required Reading:

  1. Chapter 3.2-3.3, VGSM
  2. Chapter 4.1-4.2, VGSM

Note/Slide Files: lecture2-handout-4up.pdf (424 KB) lecture2-handout.pdf (452 KB)

S ShiboskiCB 6702
Thurs 1/14/2010
10:30 AM-12:30 PM		Lab

Multiple Linear Regression

Assignment Files: lab2.pdf (100 KB)

Assignment Answer Files: lab2.comments.pdf (294 KB)

Dataset Files: lab2.dta (3 KB)

S ShiboskiCB 6704
Tues 1/19/2010
10:30 AM-12:00 PM		Lecture

Categorical Predictors

Ordinal and nominal predictors; tests for trend

Required Reading:

  1. Chapter 4.3, VGSM

Note/Slide Files: lecture3-handout-4up.pdf (803 KB) lecture3-handout.pdf (785 KB)

S ShiboskiCB 6702
Thurs 1/21/2010
10:30 AM-12:30 PM		Lab

Categorical Predictors

Assignment Files: lab3-stata10.pdf (80 KB) lab3.pdf (81 KB)

Assignment Answer Files: lab3.comments.pdf (68 KB) lab3.do (1 KB)

Dataset Files: lab3.dta (7 KB)

S ShiboskiCB 6704
Tues 1/26/2010
10:30 AM-12:00 PM		Lecture

Confounding and Mediation

Confounding and mediation and adjustment

Required Reading:

  1. Chapter 4.4-4.5, VGSM

Optional Reading:

  1. Cole & Hernan, IJE, 2002
  2. Hernan, Epidemiology, 2004

Note/Slide Files: lecture4.4up.pdf (302 KB) lecture4.pdf (233 KB)

E VittinghoffCB 6702
Tues 1/26/2010
12:00 PM-1:00 PM		Other

Homework session

S ShiboskiCB 6702
Thurs 1/28/2010
10:30 AM-12:30 PM		Lab

Confounding and Mediation

Assignment Files: lab4.pdf (58 KB)

Assignment Answer Files: lab4.comments.pdf (53 KB)

STATA Files: lab4.dta (153 KB)

E VittinghoffCB 6704
Tues 2/2/2010
10:30 AM-12:00 PM		Lecture

Interaction

Conceptual introduction, product terms, testing for interactions, lincom statements

Required Reading:

  1. Chapter 4.6, VGSM

Note/Slide Files: lecture5-4up.pdf (306 KB) lecture5.pdf (228 KB)

Assignment:
Homework #2: Due Date 2/9/10

Assignment Files: hwk2.pdf (42 KB)

STATA Files: hwk2.dta (39 KB)

E VittinghoffCB 6702
Thurs 2/4/2010
10:30 AM-12:30 PM		Lab

Interaction

Assignment Files: lab5.pdf (81 KB)

Assignment Answer Files: lab5.comments.pdf (93 KB)

STATA Files: lab5.dta (61 KB)

E VittinghoffCB 6704
Tues 2/9/2010
10:30 AM-12:00 PM		Lecture

Model Diagnostics

Linearity, normality, constant variance; influential points

Required Reading:

  1. Chapter 4.7, VGSM

Note/Slide Files: lecture6-4up.pdf (3676 KB) lecture6.pdf (2801 KB)

E VittinghoffCB 6702
Tues 2/9/2010
12:00 PM-1:00 PM		Other

Homework session

S ShiboskiCB 6702
Thurs 2/11/2010
10:30 AM-12:30 PM		Lab

Model Diagnostics

Assignment Files: lab6.pdf (91 KB)

STATA Files: lab6.dta (18 KB)

E VittinghoffCB 6704
Tues 2/16/2010
10:30 AM-12:00 PM		Lecture

Predictor Selection

Causal diagrams, three inferential goals; number of predictors, colinearity

Required Reading:

  1. Chapter 5, VGSM

Assignment:
Homework #3: Due Date 2/23/10

E VittinghoffCB 6702
Thurs 2/18/2010
10:30 AM-12:30 PM		Lab

Predictor Selection

E VittinghoffCB 6704
Tues 2/23/2010
10:30 AM-12:00 PM		Lecture

Binary Outcome Data

Contingency tables; binary outcomes; measures of association; logistic model

Required Reading:

  1. Chapter 3.4, VGSM
  2. Chapter 6.1, VGSM

Assignment:
Homework #4: Due Date 3/9/10

S ShiboskiCB 6702
Tues 2/23/2010
12:00 PM-1:00 PM		Other

Homework session

S ShiboskiCB 6702
Thurs 2/25/2010
10:30 AM-12:30 PM		Lab

Binary Outcome Data

S ShiboskiCB 6704
Tues 3/2/2010
10:30 AM-12:00 PM		Lecture

Multiple Logistic Regression

Multiple logistic regression; confounding; interaction

Required Reading:

  1. Chapter 6.2.1-6.2.3, VGSM
S ShiboskiCB 6702
Thurs 3/4/2010
10:30 AM-12:30 PM		Lab

Multiple Logistic Regression

S ShiboskiCB 6704
Tues 3/9/2010
10:30 AM-12:00 PM		Lecture

Prediction and Model Diagnostics

Prediction; model assessment; outliers; goodness of fit

Required Reading:

  1. Chapter 6.2.4-6.2.5 & Chapter 6.4, VGSM

Assignment:
Homework #5: Due Date 3/16/10

Final Exam Due Date: 3/19/10

S ShiboskiCB 6702
Tues 3/9/2010
12:00 PM-1:00 PM		Other

Homework session

S ShiboskiCB 6702
Thurs 3/11/2010
10:30 AM-12:30 PM		Lab

Prediction and Model Diagnostics

S ShiboskiCB 6704
Tues 3/16/2010
10:30 AM-12:00 PM		Lecture

Case Control Studies

Case-control study; conditional logistic regression; generalized linear models

Required Reading:

  1. Chapter 6.3 & 6.5 VGSM
S ShiboskiCB 6702