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Syllabus

Biostatistical Methods for Clinical Research I BIOSTAT200

Date/Time Activity Topic/Content Faculty Locations
Tues 9/22/2009
10:30 AM-12:30 PM		Lecture

Introduction, data presentation, numerical summary measures

Types of data; Tables; Graphs; Measures of central tendency; Measures of spread; Chebyshev’s inequality and the empirical rule

Required Reading:

  1. Chapter 1, 2 and 3 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 9/24/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Assignment One
(All HW is from Pagano & Gauvreau unless otherwise noted. HW questions are at end of chapter)
Chapter Two: 1 - 7; 16 - 20
Chapter Three: 1 - 3; 5, 9, 11, 13, 15

B Jersky
U TBA		CB 6702
CB 6704
Thurs 9/24/2009
12:00 PM-1:00 PM		Other

Office Hours

Students from Akber through Fogler - email HW to Will Charlton
Students from Fox through Le - email HW to Michelle Rook
Students from Lee through Rofagha - email HW to Grace Shih
Students from Roubinan through Yoo - email HW to Ramya Srinivasan

Assignment Answer Files: Biostat 200 Homework One (2).doc (27 KB) Biostat 200 HW One(3).doc (30 KB)

B JerskyCB 6702
Tues 9/29/2009
10:30 AM-12:30 PM		Lecture

Probability and theoretical probability distributions

Elementary concepts of probability and applications to health sciences; Binomial distribution; Normal distribution

Required Reading:

  1. Chapter 6 and 7 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 10/1/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Assignment Two:
Chapter Six: 1 - 6; 13, 18
Chapter Seven: 1 - 3; 6, 7, 9, 12, 13, 18 - 20

B Jersky
U TBA		CB 6702
CB 6704
Thurs 10/1/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Statistics Ch 6 & 7 solutions.doc (29 KB)

B JerskyCB 6702
Tues 10/6/2009
10:30 AM-12:30 PM		Lecture

Sampling distribution of the mean; confidence intervals

Sampling distributions; The Central Limit Theorem; The concept of inference; Confidence intervals; Student’s t-distribution

Required Reading:

  1. Chapter 8 and 9 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 10/8/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Assignment 3:
Chapter 8: 1 - 7, 12
Chapter 9: 3 - 5, 8

B Jersky
U TBA		CB 6702
CB 6704
Thurs 10/8/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Statistics Ch 8 & 9 solutions.doc (29 KB)

B JerskyCB 6702
Tues 10/13/2009
10:30 AM-12:30 PM		Lecture

Hypothesis testing

Hypothesis testing – general concepts; Types of error; Significance; Power; p-values; Sample size estimation

Required Reading:

  1. Chapter 10 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 10/15/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Assignment Four
Chapter Ten: 1 - 8, 11, 13
Chapter 14: 1 - 3, 8

B Jersky
U TBA		CB 6702
CB 6704
Thurs 10/15/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Chapter 14 HW solutions.doc (24 KB) Statistics Ch 10 solutions.doc (29 KB)

B JerskyCB 6702
Tues 10/20/2009
10:30 AM-12:30 PM		Lecture

Comparing two means

Paired samples; Independent samples

Required Reading:

  1. Chapter 11 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 10/22/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Assignment Five
Chapter 11: 1, 2, 7, 9, 13

B Jersky
U TBA		CB 6702
CB 6704
Thurs 10/22/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Statistics Chapter 11 Solutions.doc (26 KB)

B JerskyCB 6702
Tues 10/27/2009
10:30 AM-12:30 PM		Lecture

ANOVA; non-parametric inference

Comparing more than 2 means; Multiple comparisons; Selected non-parametric methods

Required Reading:

  1. Chapter 12 and 13 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 10/29/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Chapter 12: 1, 2, 10, 11
Chapter 13: 1 - 5, 13, 16

B Jersky
U TBA		CB 6702
CB 6704
Thurs 10/29/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Statistics HW Ch12.doc (22 KB)

B JerskyCB 6702
Tues 11/3/2009
10:30 AM-12:30 PM		Lecture

Inference on proportions

Sampling distribution of proportions; Inference for proportions; Sample size estimation

Required Reading:

  1. Chapter 14 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 11/5/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Chapter 14: 11, 12

B Jersky
U TBA		CB 6702
CB 6704
Thurs 11/5/2009
12:00 PM-1:00 PM		Other

Office Hours

B JerskyCB 6702
Tues 11/10/2009
10:30 AM-12:30 PM		Lecture

The chi-squared test

2 X 2 tables; r X c tables; McNemar’s test; Odds ratios

Required Reading:

  1. Chapter 15 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 11/12/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Chapter 15: 4, 5, 8, 9, 10, 12, 16

B Jersky
U TBA		CB 6702
CB 6704
Thurs 11/12/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Biostat Ch 16 HW Solutions.doc (20 KB) Ch 15 HW solutions.doc (22 KB)

B JerskyCB 6702
Tues 11/17/2009
10:30 AM-12:30 PM		Lecture

Correlation and simple linear regression

Scatterplots; Correlation coefficients; The regression model; Assumptions for regression

Required Reading:

  1. Chapter 17 and 18 (Pagano & Gauvreau)
B JerskyCB 6702
Thurs 11/19/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment:
Chapter 17: 1 - 5

B Jersky
U TBA		CB 6702
CB 6704
Thurs 11/19/2009
12:00 PM-1:00 PM		Other

Office Hours

Assignment Answer Files: Biostat Ch 17 Solutions.doc (21 KB)

B JerskyCB 6702
Tues 11/24/2009
10:30 AM-12:30 PM		Lecture

Multiple Regression

Assignment Answer Files: Biostat Ch 18 selected HW Solutions.doc (28 KB)

B JerskyCB 6702
Tues 12/1/2009
10:30 AM-12:30 PM		Lecture

Logistic Regression

Assignment Answer Files: Biostat Ch 19 Solutions.doc (21 KB)

B JerskyCB 6702
Thurs 12/3/2009
10:30 AM-12:00 PM		Lab

Lab

Assignment Answer Files: Biostat Ch 20 solutions.doc (21 KB)

B Jersky
U TBA		CB 6702
CB 6704
Thurs 12/3/2009
12:00 PM-1:00 PM		Other

Office Hours

B JerskyCB 6702
Tues 12/8/2009
10:30 AM-12:30 PM		Lecture

Final Exam

B JerskyCB 6702
Thurs 12/10/2009
10:30 AM-12:00 PM		Lab

Open

B Jersky
U TBA		CB 6702
CB 6704
Thurs 12/10/2009
12:00 PM-1:00 PM		Other

Open

B JerskyCB 6702