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Syllabus

Biostatistical Methods for Clinical Research IV BIOSTAT210

Date/Time Activity Topic/Content Faculty Locations
Tues 9/22/2009
10:30 AM-12:00 PM		Lecture

Introduction

Review of regression; major model questions, properties of a good regression model

Required Reading:

  1. Steyerberg Ch 2.4

Note/Slide Files: lecture1 handout.pdf (321 KB)

Assignment:
Homework #1.

Assignment Files: actg5235.dta (2 KB) hw1-sim.do (2 KB) hw1.pdf (82 KB)

Assignment Due Date: 10/6/09

Assignment Answer Files: hw1 solution.pdf (124 KB)

D GliddenCB 6704
Tues 9/29/2009
10:30 AM-12:00 PM		Lecture

Preliminaries

Bias, variability, confidence interval coverage, bootstrap and cross-validation

Required Reading:

  1. Steyerberg Ch. 4

Note/Slide Files: lecture2 slides.pdf (226 KB)

D GliddenCB 6704
Tues 10/6/2009
10:30 AM-12:00 PM		Lecture

Bias/Variance Trade Off

Stein’s paradox, optimism and over-fitting in models

Required Reading:

  1. Steyerberg Ch. 5

Note/Slide Files: lecture3 slides.pdf (395 KB)

D GliddenCB 6704
Tues 10/6/2009
3:15 PM-4:15 PM		Section

Section

D GliddenCB 6704
Tues 10/13/2009
10:30 AM-12:00 PM		Lecture

Functional Form

Splines, smoothing, categorizing continuous predictors

Required Reading:

  1. Steyerberg Ch. 9

Note/Slide Files: lect4 slides.pdf (520 KB)

Assignment:
Homework #2

Assignment Files: hw2.dta (149 KB) hw2.pdf (37 KB)

Assignment Due Date: October 27, 2009

Assignment Answer Files: hw2 soln.pdf (141 KB)

STATA Files: lab3 solution.pdf (185 KB) lab3.dta (79 KB) lab3.pdf (55 KB)

D GliddenCB 6704
Tues 10/20/2009
10:30 AM-12:00 PM		Lecture

Missing Values

Types of missing data, MCAR/MAR/NAR

Required Reading:

  1. Steyerberg Ch. 7

Optional Reading:

  1. Discussion of MAR v MCAR missingness

Note/Slide Files: lecture 5 slides.pdf (146 KB)

STATA Files: lab4.dta (217 KB) lab4.pdf (48 KB)

D GliddenCB 6704
Tues 10/20/2009
3:15 PM-4:15 PM		Section

Section

D GliddenCB 6704
Tues 10/27/2009
10:30 AM-12:00 PM		Lecture

Multiple Imputation

Choice of imputation model, ICE package

Required Reading:

  1. Steyerberg Chs 7.4, 8

Optional Reading:

  1. Multiple Imputation: A Primer
  2. A Gentle Introduction to Multiple Imputation

Note/Slide Files: lect6 handout.pdf (160 KB)

STATA Files: lab4.dta (217 KB) lab5.pdf (55 KB)

D GliddenCB 6704
Tues 11/10/2009
10:30 AM-12:00 PM		Lecture

Model Selection

Stepwise, all subsets, a priori, cross-validation

Required Reading:

  1. Steyerberg Chs 10-11

Note/Slide Files: lecture7-slides.pdf (1258 KB)

Assignment:
Homework #3

Assignment Files: hw3.dta (7 KB) hw3.pdf (52 KB)

Assignment Due Date: 11/17/09

STATA Files: lab6 discussion.pdf (78 KB) lab6-cv.do (1 KB) lab6-learn.dta (94 KB) lab6.pdf (71 KB)

D GliddenCB 6704
Tues 11/17/2009
10:30 AM-12:00 PM		Lecture

Model Validation

Calibration v. prediction, quantifying tests of model fit

Required Reading:

  1. Steyerberg Ch. 15, 17

Optional Reading:

  1. Altman and Royston

Note/Slide Files: lecture8-slides.pdf (428 KB)

Assignment:
Homework #4

Assignment Files: hw4.dta (21 KB) hw4.pdf (33 KB)

D GliddenCB 6704
Tues 11/17/2009
3:15 PM-4:15 PM		Section

Section

Assignment:
Lab #7

Assignment Files: lab7.dta (139 KB) lab7.pdf (56 KB)

D GliddenCB 6704
Tues 11/24/2009
10:30 AM-12:00 PM		Lecture

Comparing Models

Required Reading:

  1. Steyerberg Ch. 15

Optional Reading:

  1. Risk Stratification

Note/Slide Files: lecture9-slides.pdf (340 KB)

D GliddenCB 6704
Tues 12/1/2009
10:30 AM-12:00 PM		Lecture

Wrap Up and Review

Note/Slide Files: lecture 10-slides.pdf (128 KB)

D GliddenCB 6704
Tues 12/1/2009
3:15 PM-4:15 PM		Section

Section

D GliddenCB 6704